ADD/ADHD - disturbance of the Dopamine, Norepinephrine,
Epinephrine system. PEA is also an important neurotransmitter in focus.
Sleep disturbance - many factors that can influence, either
too high excitatory neurotransmitters or too little inhibitory neurotransmitters.
Low serotonin and therefore low melatonin are often associated with early
morning awakening. Poor quality of sleep is often not diagnosed in those with
fatigue, even though the patient may be getting enough hours of sleep.
Menopause and PMS - often associated with low serotonin
state. Mood is affected because Estrogen helps the enzyme that converts 5
HTP to serotonin. During the premenstrual phase or menopause there is lower
effective estrogen and therefore less serotonin.
Depression - more effective control of depression with specific
amino acid therapy can be achieved by understanding the imbalances with testing.
Depression can be low Serotonin, Low Dopamine, Low Epinephrine or any combination
of these deficiencies.
Fatigue - Usually low excitatory neurotransmitters, and
many times these are not as high due to stress of the adrenal glands which
decreases epinephrine output.
Anxiety - imbalance of calming/inhibitory neurotransmitters
with overabundance of stimulatory neurotramsmitters.
Neurotransmitters Available for Testing:
- GABA-the major inhibitory neurotransmitter of the brain, keeps the excitatory
system from becoming overactive. Relaxes and calms you down. Low levels
are associated with substance abuse, anxiety, panic attacks, seizures, and
- Serotonin- important for integrating many areas of brain function. Plays
a major role in mood and emotion, increases feelings of calm and contentment.
Regulates pathways involved in food craving and vomiting. Low levels result
in depressed mood, anxiety, insomnia, food cravings, drug/alcohol abuse,
eating disorders, restless leg syndrome, migraine headaches.
- Glutamate is the major excitatory neurotransmitter in the brain. Increased
levels of glutamate can cause death to the neurons (nerve cells) in the
brain. Dysfunction in glutamate levels are involved in many neurodegenerative
diseases such as Alzheimer's disease, Parkinson's, Huntington's, and Tourette's.
High levels also contribute to Depression, OCD, and Autism.
- Epinephrine also known as adrenaline is a neurotransmitter and hormone
essential to metabolism. Regulates attention, mental focus, arousal, and
- Norepinephrine important for mood, focused attention, and stress response.
Excess levels result in mania, high blood pressure, anxiety.
- Dopamine plays a significant role in the cardiovascular, renal, hormonal,
and central nervous systems. Involved in motor control, behavior, pleasure-reward,
addiction, drive, motivation, concentration, and memory.
- PEA promotes energy, elevates mood, involved with attention, focus, and
cognition. Implicated in migraines, ADD/ADHD, psychotic disorders, and Autism.
- Histamine is involved in allergy and inflammatory response. Excess histamine
is associated with headaches, migraines, depression, allergies, obsessions.